Modomics - A Database of RNA Modifications


NameHepatocellular carcinoma (A:m6A)
DescriptionVIRMA is upregulated in HCC. VIRMA induced m6A methylation on the 3′ UTR of GATA3 pre-mRNA, leading to the separation of the RNA-binding protein HuR and the degradation of GATA3 pre-mRNA, leading to altered GATA3 expression and thereby facilitating the malignant phenotypes of hepatoma cells.
Related RNA reactionA:m6A
Found in RNApre-mRNA
Modified TranscriptGATA3
Mapping TechnologyMeRIP-seq
Quantification techniques

Enzymes connected to Hepatocellular carcinoma:

Acronym Full name Enzyme Role Organism Comment
VIRMA vir like m6A methyltransferase associated oncogene Homo sapiens


ID Title Authors Journal Details PubMed Id DOI
1046 KIAA1429 contributes to liver cancer progression through N6-methyladenosine-dependent post-transcriptional modification of GATA3. Tian Lan Mol Cancer [details] 31856849 10.1186/s12943-019-1106-z