Modomics - A Database of RNA Modifications


NameBreast cancer (A:m6A)
Descriptionm6A levels are reduced in breast cancer samples due to a decrease in m6A methylases expression and an increase in demethylases expression; expression levels of METTL3, METTL14, WTAP and FTO were correlated with poor survival and cancer progression; m6A higher levels suppress cancer cell viability, inhibit MDA-MB-231 colony-formation abilities and cell migratory abilities.Expression levels of writers and readers differes according to the subtype of breast cancer ( luminal A/B vs. triple negative).
Related RNA reactionA:m6A
Modified TranscriptNone
Mapping TechnologyNone
Quantification techniquesm6A quantification, ELISA

Enzymes connected to Breast cancer:

Acronym Full name Enzyme Role Organism Comment
ALKBH5 RNA demethylase ALKBH5 None Homo sapiens
FTO Alpha-ketoglutarate-dependent dioxygenase FTO None Homo sapiens
METTL14 N6-adenosine-methyltransferase non-catalytic subunit None Homo sapiens
METTL3 N6-adenosine-methyltransferase 70 kDa subunit None Homo sapiens
WTAP Pre-mRNA-splicing regulator WTAP None Homo sapiens


ID Title Authors Journal Details PubMed Id DOI
985 Changes of N6-methyladenosine modulators promote breast cancer progression. Lianpin Wu BMC Cancer [details] 30953473 10.1186/s12885-019-5538-z