Modomics - A Database of RNA Modifications


NameTemporal Lobe Epilepsy (C:U)
DescriptionIncreased C-to-U RNA editing mediated by APOBEC1 leads to neuronal gain-of-function through presynaptic activity of RNA-edited GlyRs, resulting in facilitation of neurotransmitter release
Related RNA reactionC:U
Found in RNAmRNA
Modified TranscriptGLYR
Mapping TechnologyNone
Quantification techniquesRT-PCR

Enzymes connected to Temporal Lobe Epilepsy:

Acronym Full name Enzyme Role Organism Comment
APOBEC1 apolipoprotein B mRNA editing enzyme catalytic subunit 1 None Homo sapiens


ID Title Authors Journal Details PubMed Id DOI
1121 A Novel RNA Editing Sensor Tool and a Specific Agonist Determine Neuronal Protein Expression of RNA-Edited Glycine Receptors and Identify a Genomic APOBEC1 Dimorphism as a New Genetic Risk Factor of Epilepsy. Svenja Kankowski Front Mol Neurosci [details] 29375302 10.3389/fnmol.2017.00439