Modomics - A Database of RNA Modifications


NameOsteosarcoma (A:m6A)
DescriptionExpression level of METTL3 are up-regulated in human OS tissues and OS cell lines. METTL3 promotes osteosarcoma cell progression by regulating the m6A level of LEF1 and activating Wnt/b-catenin signaling pathway.
Related RNA reactionA:m6A
Found in RNAmRNA
Modified TranscriptLEF1
Mapping Technology
Quantification techniquesMeRIP-qPCR

Enzymes connected to Osteosarcoma:

Acronym Full name Enzyme Role Organism Comment
METTL3 N6-adenosine-methyltransferase 70 kDa subunit oncogene Homo sapiens


ID Title Authors Journal Details PubMed Id DOI
1101 The m6A methyltransferase METTL3 promotes osteosarcoma progression by regulating them6A level of LEF1. Miao W Biochem Biophys Res Commun [details] 31253399 10.1016/j.bbrc.2019.06.128