Modomics - A Database of RNA Modifications


NameChronic Myeloid Leukemia (A:I)
DescriptionUpregulation of ADAR1 p-150 isoform, in the blastic crisis of CML, may be related to the activation of inflammatory pathways. An inflammatory mediator-driven isoform switch, which favors ADAR1 p150 expression, drives the expansion of malignant progenitors and contributes to CML progression.
Related RNA reactionA:I
Found in RNAmRNA
Modified TranscriptNone
Mapping TechnologyRNA-seq
Quantification techniquesqRT-PCR

Enzymes connected to Chronic Myeloid Leukemia:

Acronym Full name Enzyme Role Organism Comment
ADAR Double-stranded RNA-specific adenosine deaminase oncogene Homo sapiens


ID Title Authors Journal Details PubMed Id DOI
997 ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia. Qingfei Jiang Proc Natl Acad Sci U S A [details] 23275297 10.1073/pnas.1213021110