Modomics - A Database of RNA Modifications


NameAlazami syndrome (N:Nm)
Description2'-O-methylation of the U6 snRNA is impaired; it might influence RNA structure formation and thus splicing fidelity.
Related RNA reactionN:Nm
Found in RNAsnRNA
Modified Transcriptspliceosomal U6 small nuclear RNA
Mapping TechnologyRiboMeth-Seq
Quantification techniquesNone

Enzymes connected to Alazami syndrome:

Acronym Full name Enzyme Role Organism Comment
LARP7 La ribonucleoprotein 7, transcriptional regulator None Homo sapiens


ID Title Authors Journal Details PubMed Id DOI
964 The Alazami Syndrome-Associated Protein LARP7 Guides U6 Small Nuclear RNA Modification and Contributes to Splicing Robustness. Daniele Hasler Mol Cell [details] 32017898 -