Modomics - A Database of RNA Modifications


NameAcute Myeloid Leukemia (N:Nm)
DescriptionDecrease in 2'-O-Me due to knock-out of SNORD42A leads to a decrease in ribosomal proteins translation. 2'-O-Me impacts global protein translation by fine-tuning the synthesis of the translational machinery.
Related RNA reactionN:Nm
Found in RNArRNA
Modified TranscriptrRNA 18S ( position U116)
Mapping TechnologyRiboMeth-Seq
Quantification techniquesqPCR

Enzymes connected to Acute Myeloid Leukemia:

Acronym Full name Enzyme Role Organism Comment


ID Title Authors Journal Details PubMed Id DOI
962 Site-specific methylation of 18S ribosomal RNA by SNORD42A is required for acutemyeloid leukemia cell proliferation. Pauli C Blood [details] 32097467 S0006-4971(20)61978-4