DNAmoreDB - A Database of Deoxyribozymes

Abstract:

In vitro selection experiments yield unexpected results. An RNA‐cleaving DNA enzyme that was selected in the presence of Mg2+ ions is much more efficient with Ca2+ as the cofactor. The result is even more surprising because of the lower hydrolytic efficiency of Ca2+ itself.

DNAzymes linked to this article:

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Name	Isolated sequence	Length	Reaction
class 1	AAGCTCTCTCAGCGAGACGAAATAGGGAGTTAGCAGCACGAGGTTACACTTTTATCCTCTCCCAAAGTAGGGAC	74	RNA cleavage
class 3	GGCATGTACCCAAGAAGGGGTGGAGCCGGCAGTGACCCCTGCGAGTAGGGAAGCCCAAGAACGAAGAGTTAAGC	74	RNA cleavage
class 4	ATGCTGTTGCTCTGTCAGCGGACACGAAATAGTGGGTCGCGATGCTGAATAATCACGGCGAAAGTGGTTGCCTA	74	RNA cleavage
class 5	CAGATGTGAAGTTAGAGCTTTGCCAGCnTCGTTAGTAGAGTCAGCGCACAGGGGAAGATTGTATGTCTATAG	72	RNA cleavage
class 6	TAGGAAGTAGGGACCTACAAGTTGTCATTGTAACTGAGTTCTGCCAGCTGsACGAAATAGTCAGGAGTTAG	71	RNA cleavage
class 7	CGTCATGCGAAAAGAATGGTGAGATTTGCCAGCsGTCGAGTAGTAGTCCAGGGAACATTGCCCGGGGGATT	71	RNA cleavage
class 8	AGAACGGTAGAGTGCNGGGGGTGCAGTTGAGCTTTGTCAGCsACACGAATAAGAGTCTCGTAGGATTCACCAAG	74	RNA cleavage
Mg5 (class 2)	AGCACGCATGACTTTGATGCCACGTAAAGTGAAAGAGCTGTTGATCTGTCAGCGACACGAAATGGTGATGCCCT	74	RNA cleavage

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