Abstract:

Closing the loop: The artificial 6BX22 deoxyribozyme (in green) synthesizes naturally occurring lariat RNAs in one step from readily available linear RNA substrates. The exquisite site selectivity of this macrocyclization reaction - which can form a 1597-membered ring in 72% yield with < 0.1 % side products - highlights the utility of catalytic DNA for transformations that are not possible with traditional synthetic methods. (Chemical Equation Presented).