DNAmoreDB - A Database of Deoxyribozymes

Published on 2011 in Angew. Chem. Int. Ed. Engl. volume 50 issue 49.

PubMed ID: 21994131

DOI:10.1002/anie.201104976

Abstract:

A new reaction for DNA : DNA is shown to catalyze Ni2+‐dependent reductive amination involving the N2‐amine of a guanosine nucleobase (see picture). This finding expands the repertoire of nucleic acid catalysis to include reductive amination, an important natural biosynthetic reaction that has practical synthetic utility.

DNAzymes linked to this article:

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Name	Isolated sequence	Length	Reaction
8QA102	AAGGGGTAGTGCTAAACGTGAAGATGGTTTGGGTAATCTC	40	Reductive amination
8QA103	AATGGCAGTGAGAAACGTATGGTCACATGTATGTGGTCAC	40	Reductive amination
8QA104	AGGGGTAGTGCCAAACGTGGCCTGGTTTGATGATTCGGCC	40	Reductive amination
8QA107	AAGGGGTAGTGCCAAACGTGGAAACCTGTGGATAAGGTCC	40	Reductive amination
8QA108	AAGGGGTAGTGCCAAACGTACGAAGGCTTCATTACCGACC	40	Reductive amination
8QA109	AAGAGGCACGTGCTAAACGTGGAAGGACTTCGGTTCTCCA	40	Reductive amination
8QA111	GGGGGCCGCGATTAAATGTTGTCATGCAGCTCTCTGAGGC	40	Reductive amination
8QA115	AGGGGCAGTGCTAAACGTGTACAGACTAAAATGGTCTGTC	40	Reductive amination
8QA122	AAGGGGCACGTGCTAAACGTGGAAGGACTTCGGTTCTCCC	40	Reductive amination
8QA124	AAGGGGCAGTGCTAAACGTGGACAGGAATCATAAGTGTCA	40	Reductive amination

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