| Reaction | Substrates | Product | Metal ion | Seq description | Thymine dimer repair |
X: T=T is a thymine dimer S: AGGATCTACATGTAT=TGTGTGCGTACGAGTATATGG-N40-GTCTCAATCGGTCTGTATC |
repaired sequences |
light Serotonin |
N 40 |
|---|
| Buffer conditions |
|---|
| 20 mM Sodium phosphate pH 7.0, 40 mM NaCl, 10 μM Serotonin |
| kcat/ kobs |
|---|
| kobs = 0.20 min-1 |
| Catalytic region of the DNAzyme |
|---|
| TAAGTCGGATGGAGGGATCCGTTGGCACATGTAGTCACGT |
| Notes |
|---|
| Self repair of the Thymine dimer located on the 5'-end of the DNA library (primer binding region). |
| Year of Publication | First Author | Laboratory | Title | PubMed ID | DOI | Reaction |
|---|---|---|---|---|---|---|
| 2009 | R E Thorne | D Sen | A deoxyribozyme, Sero1C, uses light and serotonin to repair diverse pyrimidine dimers in DNA. | 19281822 | 10.1016/j.jmb.2009.02.064 | Thymine dimer repair |
| Year of Publication | First Author | Laboratory | Title | PubMed ID | DOI | Reaction |
|---|---|---|---|---|---|---|
| 2004 | D J-F Chinnapen | D Sen | A deoxyribozyme that harnesses light to repair thymine dimers in DNA. | 14691255 | 10.1073/pnas.0305943101 |
Thymine dimer repair |