| Reaction | Reacting groups | Substrates | Product | Linkage | Seq description | RNA cleavage |
Group 1 - 2'-OH Group 2 - vicinal phosphate |
S: *cleavage in cis, look up reference |
cleavage of single internal ribonucleotide phosphodiester | RNA phosphodiester | N 40 |
|---|
| Buffer conditions |
|---|
| 0.5 M NaCI, 50 mM HEPES pH 7.0 |
| Catalytic region of the DNAzyme |
|---|
| CCCAAGAAGGGGTGCGTAAACTGCTACCCTATTAACCTA |
| Notes |
|---|
| Sequence isolated after re-selection with randomized sequence of G3 |
| Year of Publication | First Author | Laboratory | Title | PubMed ID | DOI | Reaction |
|---|---|---|---|---|---|---|
| 1997 | C R Geyer | D Sen | Evidence for the metal-cofactor independence of an RNA phosphodiester-cleaving DNA enzyme. | 9281526 | 10.1016/s1074-5521(97)90244-1 | RNA cleavage |