Modomics - A Database of RNA Modifications

The molecule is shown in a ball-and-stick representation with the following colors for atoms :
Hydrogen (H): white Carbon (C): gray Oxygen (O): red Phosphorus (P): orange Nitrogen (N): blue Selenium (Se): gold Sulfur (S): yellow

Summary

Full namealpha-methylmonophosphate 5' cap
Short namempN
MODOMICS code new2000001551N
MODOMICS code1551N
Nature of the modified residueNatural
Residue unique ID171
Found in RNAYes
Enzymes BCDIN3D (Homo sapiens)
Found in phylogenyEukaryota

Chemical information

Sum formulaC6H11O7P
Type of moietynucleotide
Degeneracyunspecified residue
SMILESCOP([O-])(OC[C@H]1O[C@@H]%91[C@H](O)[C@@H]1O)=O.[*]%91
logP-0.3961
TPSA118.09
Number of atoms15
Number of Hydrogen Bond Acceptors 1 (HBA1)7
Number of Hydrogen Bond Acceptors 2 (HBA2)7
Number of Hydrogen Bond Donors (HBD)2
PDB no exac match , link to the most similar ligand N
HMDB (Human Metabolome Database) no exact match, link to the most similar ligand None
InChI
InChIKey

* Chemical properties calculated with Open Babel - O'Boyle et al. Open Babel: An open chemical toolbox. J Cheminform 3, 33 (2011) (link)


Download Structures

2D   .png .mol .mol2 .sdf .pdb .smi
3D   .mol .mol2 .sdf .pdb


Predicted CYP Metabolic Sites

CYP3A4 CYP2D6 CYP2C9
mpN mpN mpN

* CYP Metabolic sites predicted with SMARTCyp. SMARTCyp is a method for prediction of which sites in a molecule that are most liable to metabolism by Cytochrome P450. It has been shown to be applicable to metabolism by the isoforms 1A2, 2A6, 2B6, 2C8, 2C19, 2E1, and 3A4 (CYP3A4), and specific models for the isoform 2C9 (CYP2C9) and isoform 2D6 (CYP2D6). CYP3A4, CYP2D6, and CYP2C9 are the three of the most important enzymes in drug metabolism since they are involved in the metabolism of more than half of the drugs used today. The three top-ranked atoms are highlighted. See: SmartCYP and SmartCYP - background; Patrik Rydberg, David E. Gloriam, Lars Olsen, The SMARTCyp cytochrome P450 metabolism prediction server, Bioinformatics, Volume 26, Issue 23, 1 December 2010, Pages 2988–2989 (link)


LC-MS Information

Monoisotopic mass305.9906
Average mass226.121
[M+H]+ not available
Product ions not available
Normalized LC elution time * not available
LC elution order/characteristics not available

* normalized to guanosine (G), measured with a RP C-18 column with acetonitrile/ammonium acetate as mobile phase.

Chemical groups contained

TypeSubtype
hydrocarbonmethyl

Reactions producing alpha-methylmonophosphate 5' cap

Name
pN:mpN

Reactions starting from alpha-methylmonophosphate 5' cap

Name
mpN:mmpN

Publications

Title Authors Journal Details PubMed Id DOI
Human RNA Methyltransferase BCDIN3D Regulates MicroRNA Processing. Xhemalce B, Robson SC, Kouzarides T... Cell [details] 23063121 -

Last modification of this entry: Sept. 22, 2023